Fred missed the preseason tour of America to deal with a personal issue but is now back in training. Van de Beek, a £35m signing from Ajax in 2020, has featured in the summer friendlies but is well down the pecking order at Old Trafford.
Eric Bailly has also been told he is free to find a new club.
The Ivory Coast defender was left out of the party which travelled to the U.S. and has been training separately since the squad returned to Carrington to prepare for their Premier League opener against Wolverhampton Wanderers on Aug. 14.
Anthony Martial is set to stay with United receiving no firm interest this summer. The 27-year-old is back in training after missing the end of last season with a hamstring injury but is not yet match fit.
Meanwhile, Dean Henderson‘s proposed move to Nottingham Forest has been complicated by their pursuit of Arsenal goalkeeper Matt Turner. Forest have been negotiating a loan for Henderson with an obligation to buy but have now agreed a deal with Arsenal for Turner.